Testing Status of Agents at NTP
Daminozide
CASRN: 1596-84-5
Formula: C6 H12 N2 O3
Synonyms/Common Names:
- DIAMINOZIDE
- MONO(2,2-DIMETHYLHYDRAZIDE) BUTANEDIOIC ACID
- SUCCINIC ACID 2,3-DIMETHYLHYDRAZINE
Known Uses:
PLANT GROWTH RETARDANT
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03827) Completed
- NTIS No. PB285073
(Peer Review 03/07/1978)
Citation: Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB285073
(Peer Review 03/07/1978)
- 13-Week (Dosed-Feed)
(C03827) Completed
- NTIS No. PB285073
(Peer Review 03/07/1978)
Citation: Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,10000,50000 PPM/10 PER GROUP
- NTIS No. PB285073
(Peer Review 03/07/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03827) Report Complete
- TR-083 (NTIS No. PB285073)
(Peer Review 03/07/1978)
Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Positive
- Male Mice Equivocal
- Female Mice Negative
- Dose: 0,5000,10000 PPM/50 PER GROUP
- TR-083 (NTIS No. PB285073)
(Peer Review 03/07/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(113918) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Mouse Lymphoma
(001610) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Inconclusive
- Micronucleus
(379905) Completed
- Mice: B6C3F1
- Male Equivocal
- Salmonella (NCI)
(N-9249) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(382104) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on January 22, 2009