National Toxicology Program

CASRN: 1596-84-5

Formula: C6 H12 N2 O3

Synonyms/Common Names:

• DIAMINOZIDE
• MONO(2,2-DIMETHYLHYDRAZIDE) BUTANEDIOIC ACID
• SUCCINIC ACID 2,3-DIMETHYLHYDRAZINE

Known Uses:

PLANT GROWTH RETARDANT

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03827) Completed 
  • NTIS No. PB285073  (Peer Review 03/07/1978)
    Citation: Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03827) Completed 
  • NTIS No. PB285073  (Peer Review 03/07/1978)
    Citation: Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,10000,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03827) Report Complete 
  • TR-083 (NTIS No. PB285073)  (Peer Review 03/07/1978)
    Bioassay of Daminozide for Possible Carcinogenicity (CAS No. 1596-84-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Positive 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: 0,5000,10000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (113918) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (001610) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Inconclusive 
• Micronucleus  (379905) Completed 
  • Mice: B6C3F1
  • Male Equivocal 
• Salmonella (NCI)  (N-9249) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (382104) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative