National Toxicology Program

CASRN: 1163-19-5

Formula: C12-Br10-O

Synonyms/Common Names:

• 1,1'-OXYBIS(2,3,4,5,6-PENTABROMOBENZENE) (9CI)

Known Uses:

FLAME RETARDANT. FOR NITRILE RESINS, POLYESTER AND TEXTILE COATINGS. (TDB)

Nomination Background

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55287) Completed 
  • NTIS No. PB86-247780  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55287) Completed 
  • NTIS No. PB86-247780  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,3100,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C55287) Report Complete 
  • TR-309 (NTIS No. PB86-247780)  (Peer Review 08/14/1985)
    Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) In F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Some Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice No Evidence 
  • Dose: 0,25000,50000 PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Dosed-Feed)  (S0210) Completed 
  • Citation: J. OF TOXIC. AND ENVIRON HEALTH VOL 22: 405-415 (1987) DISPOSITION OF DECABROMOBIPHENYL ETHER IN RATS DOSED INTRAVENOUSLY OR BY FEEDING. S.M. EL DAREER, J.R. KALIN, K.F. TILLERY, AND D.L. HILL
  • M Rats: F344/N; M Rats: F344/N
  • Dose: IV: 1 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (856353) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (490548) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Negative 
• Micronucleus  (A36713) Completed 
  • Rats: F344
  • Male Positive 
• Salmonella  (185983) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative