National Toxicology Program

CASRN: 1067-33-0

Formula: C12-H24-O4-SN

Synonyms/Common Names:

• BIS(ACETYLOXY)DIBUTYLSTANNANE

Known Uses:

CATALYST FOR POLYMERIZATION; STABILIZER

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02028) Completed 
  • NTIS No. PB291567  (Peer Review 10/25/1978)
    Citation: Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CAS No. 1067-33-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02028) Completed 
  • NTIS No. PB291567  (Peer Review 10/25/1978)
    Citation: Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CAS No. 1067-33-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,70,315, M: 0,17,650 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02028) Report Complete 
  • TR-183 (NTIS No. PB291567)  (Peer Review 10/25/1978)
    Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CAS No. 1067-33-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Inadequate Study 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,66.5,133 (AVG), M: 0,76,152 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (092968) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (373936) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (881018) Completed 
  •  Positive 
• Salmonella  (834817) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative