Testing Information

Testing Status of Agents at NTP

2-Chloroethyltrimethylammonium chloride

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http://ntp.niehs.nih.gov/go/TS-10669-Y

CASRN: 999-81-5

Formula: C5-H13-CL-N.CL

Synonyms/Common Names:

  • CHLOROCHOLINE CHLORIDE
  • 2-CHLORO-N,N,N-TRIMETHYL-ETHANAMINIUM CHLORIDE (9CI)

Known Uses:

PLANT GROWTH REGULATOR (MERCK 1990).

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02960) Completed 
    • NTIS No. PB293627  (Peer Review 12/13/1978)
      Citation: Bioassay of (2-Chloroethyl)trimethylammonium Chloride (CCC) for Possible Carcinogenicity (CAS No. 999-81-5)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02960) Completed 
    • NTIS No. PB293627  (Peer Review 12/13/1978)
      Citation: Bioassay of (2-Chloroethyl)trimethylammonium Chloride (CCC) for Possible Carcinogenicity (CAS No. 999-81-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,3150,14700, M: 0,1200,20000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 135-WEEK (Dosed-Feed)  (C02960) Report Complete 
    • TR-158 (NTIS No. PB293627)  (Peer Review 12/13/1978)
      Bioassay of (2-Chloroethyl)trimethylammonium Chloride (CCC) for Possible Carcinogenicity (CAS No. 999-81-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,1500,3000, M: 0,500,2000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (022395) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • In Vitro Cytogenetics (CA/SCE)  (564198) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (899913) Completed 
    •  Negative 
  • Salmonella  (698498) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (752647) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

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Web page last updated on January 22, 2009