Testing Status of Agents at NTP
Acetohexamide
CASRN: 968-81-0
Formula: C15 H20 N2 O4 S
Synonyms/Common Names:
- 4-ACETYL-N-((CYCLOHEXYLAMINO)CARBONYL)BENZENESULFONAMIDE (9CI)
- DYMELOR
Known Uses:
ORAL HYPOGLYCEMIC AGENT, ANTIDIABETIC AGENT (MERCK 1989)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03247) Completed
- NTIS No. PB284673
(Peer Review 03/06/1978)
Citation: Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB284673
(Peer Review 03/06/1978)
- 14-Day (Dosed-Water)
(C10667) On Test
- Chicks: Sherman
- 13-Week (Dosed-Feed)
(C03247) Completed
- NTIS No. PB284673
(Peer Review 03/06/1978)
Citation: Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0) - Rats: F344/N; Mice: B6C3F1
- Dose: MR: 0,1200,30000, FM: 0,2500,40000 PPM/10 PER GROUP
- NTIS No. PB284673
(Peer Review 03/06/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03247) Report Complete
- TR-050 (NTIS No. PB284673)
(Peer Review 03/06/1978)
Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,10000,20000, M: 0,7500,15000 (AVG) PPM/35 PER GROUP
- TR-050 (NTIS No. PB284673)
(Peer Review 03/06/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(722971) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Not Tested
- Mouse Lymphoma
(677347) Completed
- Negative
- Salmonella (NCI)
(N-9348) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(576628) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on January 22, 2009