Testing Information

Testing Status of Agents at NTP

Acetohexamide

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http://ntp.niehs.nih.gov/go/TS-10667-R

CASRN: 968-81-0

Formula: C15 H20 N2 O4 S

Synonyms/Common Names:

  • 4-ACETYL-N-((CYCLOHEXYLAMINO)CARBONYL)BENZENESULFONAMIDE (9CI)
  • DYMELOR

Known Uses:

ORAL HYPOGLYCEMIC AGENT, ANTIDIABETIC AGENT (MERCK 1989)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03247) Completed 
    • NTIS No. PB284673  (Peer Review 03/06/1978)
      Citation: Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0)
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Water)  (C10667) On Test 
    • Chicks: Sherman
  • 13-Week (Dosed-Feed)  (C03247) Completed 
    • NTIS No. PB284673  (Peer Review 03/06/1978)
      Citation: Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0,1200,30000, FM: 0,2500,40000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03247) Report Complete 
    • TR-050 (NTIS No. PB284673)  (Peer Review 03/06/1978)
      Bioassay of Acetohexamide for Possible Carcinogenicity (CAS No. 968-81-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,10000,20000, M: 0,7500,15000 (AVG) PPM/35 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (722971) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Not Tested 
  • Mouse Lymphoma  (677347) Completed 
    •  Negative 
  • Salmonella (NCI)  (N-9348) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Negative 
  • Salmonella  (576628) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Negative 

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Web page last updated on January 22, 2009