National Toxicology Program

CASRN: 756-79-6

Formula: C3-H9-O3-P

Synonyms/Common Names:

• METHYLPHOSPHONIC ACID DIMETHYL ESTER (9CI)

Known Uses:

FLAME RETARDANT; SOLVENT; HYDRAULIC FLUID; ANTIFOAM AGENT; PLASTICIZER AND STABILIZER; TEXTILE CONDITIONER AND ANTISTATIC AGENT

Short-Term Toxicity

• 14-Day (Gavage)  (C54762) Completed 
  • NTIS No. PB88-168695  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CAS No. 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54762) Completed 
  • NTIS No. PB88-168695  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CAS No. 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,250,4000, M: 0,250,8000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C54762) Report Complete 
  • TR-323 (NTIS No. PB88-168695)  (Peer Review 08/19/1986)
    Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CAS No. 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats No Evidence 
  • Male Mice Inadequate Study 
  • Female Mice No Evidence 
  • Dose: R: 0,500,1000, M: 0,1000,2000 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (202021) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (314062) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (212220) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (369588) Completed 
  •  Positive 
• Salmonella  (842521) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0117) Completed 
  • NTIS No. PB85-220143
    Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • F Mice: Swiss
  • Dose: 4175 MG/KG BODY WEIGHT