Testing Information

Testing Status of Agents at NTP

o-Toluidine hydrochloride

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http://ntp.niehs.nih.gov/go/TS-10654-W

CASRN: 636-21-5

Related: O-TOLUIDINE 95-53-4

Formula: C7 H9 N.H CL

Synonyms/Common Names:

  • 2-METHYLBENZENAMINE HYDROCHLORIDE (9CI)

Known Uses:

DYE INTERMEDIATE; PHOTOGRAPHIC DYE; LAB REAGENT; RUBBER MANUFACTURE

Short-Term Toxicity

  • 1-WEEK (Dosed-Feed)  (C02335B) Completed 
    • TOX-44 (NTIS No. PB96-188321)  (Toxicity Peer Review 08/00/1995)
      Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CAS No. 88-72-2) ando-Toluidine Hydrochloride (CAS No. 636-21-5) Administered in Feed to Male F344/N Rats
    • Rats: F344/N
  • 14-Day (Dosed-Feed)  (C02335) Completed 
    • NTIS No. PB290908  (Peer Review 10/25/1978)
      Citation: Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 636-21-5)
    • Rats: F344/N; Mice: B6C3F1
  • 26-WEEK (Dosed-Feed)  (C02335B) Report Complete 
    • TOX-44 (NTIS No. PB96-188321)  (Toxicity Peer Review 08/00/1995)
      Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CAS No. 88-72-2) ando-Toluidine Hydrochloride (CAS No. 636-21-5) Administered in Feed to Male F344/N Rats
    • Rats: F344/N
    • Dose: O AND 0 ALTERED MICROFLORA; 20/GRP; 5000 PPM; 60/GRP
  • 13-Week (Dosed-Feed)  (C02335) Completed 
    • NTIS No. PB290908  (Peer Review 10/25/1978)
      Citation: Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 636-21-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,1000,50000, M: 0,3100,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 148-WEEK (Dosed-Feed)  (C02335) Report Complete 
    • TR-153 (NTIS No. PB290908)  (Peer Review 10/25/1978)
      Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 636-21-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (938330) Completed 
    • Mice
    • Chromosome Aberation  Not Tested 
  • In Vitro Cytogenetics (CA/SCE)  (867721) Completed 
    • Chromosome Aberation Inconclusive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (537539) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (885510) Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (531447) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (539939) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Sister Chromatid Exchanges  (938330) Completed 
    • Mice
    • Sister Chromatid  Positive 

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Web page last updated on January 22, 2009