Testing Information

Testing Status of Agents at NTP

1,1,1,2-Tetrachloroethane

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http://ntp.niehs.nih.gov/go/TS-10651-J

CASRN: 630-20-6

Related: HALOGENATED ETHANES CS (1,1,1,2-TETRACHLOROETHANE)

Formula: C2 H2 CL4

Synonyms/Common Names:

  • ETHANE, 1,1,1,2-TETRACHLORO- (8CI)(9CI)

Known Uses:

INTERMEDIATE FOR PRODUCING TRI- AND TETRA- CHLOROETHYLENE

Short-Term Toxicity

  • 14-Day (Gavage)  (C52459) Completed 
    • NTIS No. PB83-218206  (Peer Review 12/16/1981)
      Citation: Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CAS No. 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C52459) Completed 
    • NTIS No. PB83-218206  (Peer Review 12/16/1981)
      Citation: Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CAS No. 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,5,500 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C52459) Completed 
    • TR-237 (NTIS No. PB83-218206)  (Peer Review 12/16/1981)
      Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CAS No. 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,125,250, M: 0,250,500 MG/KG/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (499400) Completed 
    • Mice
    • Chromosome Aberation  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (592953) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (264495) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (472008) Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    •  Negative 
  • Mouse Lymphoma  (503956) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Micronucleus  (299785) Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (466226) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (806178) Completed 
    •  Negative 
  • Sister Chromatid Exchanges  (499400) Completed 
    • Mice
    • Sister Chromatid  Negative 

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Web page last updated on January 22, 2009