National Toxicology Program

CASRN: 598-55-0

Formula: C2-H5-N-O2

Synonyms/Common Names:

• CARBAMIC ACID METHYL ESTER (9CI)

Known Uses:

CHEMICAL INTERMEDIATE FOR FABRIC FINISH RESINS. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C55594) Completed 
  • NTIS No. PB88-168570  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of Methyl Carbamate (CAS No. 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55594) Completed 
  • NTIS No. PB88-168570  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of Methyl Carbamate (CAS No. 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,9.38,200 MG/ML/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55594) Report Complete 
  • TR-328 (NTIS No. PB88-168570)  (Peer Review 08/19/1986)
    Toxicology and Carcinogenesis Studies of Methyl Carbamate (CAS No. 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,100,200, M: 0,500,1000 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Intravenous; Gavage)  (S0068) Completed 
  • Citation: IOANNOU, Y.M., SANDERS, J.M., & MATTHEWS, H.B.: METHYL CARBAMATE: SPECIES-DEPENDENT VARIATIONS IN METABOLISM AND CLEARANCE IN RATS & MICE, 16(3):435-440, 1988.
  • M Rats: F344/N; M Rats: F344/N; M Mice; M Mice
  • Dose: PO:40,400,1000; IV: 0.4 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (732171) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (208922) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma (NCI)  (089158) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Negative 
• Mouse Lymphoma (NCI)  (694447) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Negative 
• Micronucleus  (432500) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella (NCI)  (N-9084) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (413614) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative