National Toxicology Program

CASRN: 597-25-1

Formula: C6-H14-N-O4-P

Synonyms/Common Names:

• DMMPA
• 4-MORPHOLINYLPHOSPHONIC ACID DIMETHYL ESTER (9CI)

Known Uses:

STIMULANT FOR NERVE AGENTS IN CHEMICAL DEFENSE TRAINING; NOT PRODUCED COMMERCIALLY IN U.S.

Short-Term Toxicity

• 14-Day (Gavage)  (C54740) Completed 
  • NTIS No. PB86-186491  (Peer Review 11/02/1984)
    Citation: Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CAS No. 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54740) Completed 
  • NTIS No. PB86-186491  (Peer Review 11/02/1984)
    Citation: Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CAS No. 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,200,1600 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C54740) Report Complete 
  • TR-298 (NTIS No. PB86-186491)  (Peer Review 11/02/1984)
    Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CAS No. 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Some Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,150,300,600, FM: 0,300,600, MM: 0,150,300 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (963455) Completed 
  • Mice
  • Chromosome Aberation  Negative (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (499883) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (475748) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (652921) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Salmonella  (960949) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 
• Sister Chromatid Exchanges  (963445) Completed 
  • Mice
  • Sister Chromatid  Not Tested 
• Sister Chromatid Exchanges  (963455) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)