Testing Status of Agents at NTP
2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
Formula: C9 H6 N2 O2
Synonyms/Common Names:
- 1,3-DIISOCYANATOMETHYL BENZENE (9CI)
- ISOCYANIC ACID, METHYL-M-PHENYLENE ESTER
- TDI
Known Uses:
MANUFACTURE OF FLEXIBLE POLYURETHANE FOAMS AND COATINGS FOR LACQUER AND WOOD FINISHES
Short-Term Toxicity
- 14-Day (Gavage)
(C50533) Completed
- NTIS No. PB87-115176
(Peer Review 09/22/1982)
Citation: Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB87-115176
(Peer Review 09/22/1982)
- 13-Week (Gavage)
(C50533) Completed
- NTIS No. PB87-115176
(Peer Review 09/22/1982)
Citation: Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,.15,240 MG/KG/10 PER GROUP
- NTIS No. PB87-115176
(Peer Review 09/22/1982)
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C50533) Report Complete
- TR-251 (NTIS No. PB87-115176)
(Peer Review 09/22/1982)
Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CAS No. 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Positive
- Dose: MR: 0,30,60, FR&FM: 0,60,120, MM: 0,120,240, MG/KG/50 PER GROUP
- TR-251 (NTIS No. PB87-115176)
(Peer Review 09/22/1982)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0057) Completed
- M Rats: F344/N
- Dose: 60, 900 MG/KG
- Metabolism (Gavage)
(S0745) Completed
- Citation: DIETER, M.P., BOORMAN, G.A., JAMESON, C.W., MATTHEWS, H.B., & HUFF, J.E., THE CARCINOGENIC ACTIVITY OF COMMERCIAL GRADE TOLUENE DIISOCYANATE IN RATS AND MICE IN RELATION TO THE METABOLISM OF THE 2,4- AND 2,6-TDI ISOMERS
- M Rats: F344/N; M/F Mice: B6C3F1
- Dose: Females: 60 or 120 mg/kg, Male rats 30 or 60 mg/kg, Male mice: 120 or 240 mg/kg
Genetic Toxicology
- Chromosome Aberrations
(544551) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(161856) Completed
- Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
- Chromosome Aberation Negative
- Sister Chromatid Exchange Weakly Positive
- Drosophila
(892839) Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
- Salmonella
(654636) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Positive
- Sister Chromatid Exchanges
(544551) Completed
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)
Web page last updated on January 22, 2009