Testing Information

Testing Status of Agents at NTP

3-Chloro-2-methylpropene

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http://ntp.niehs.nih.gov/go/TS-10632-X

CASRN: 563-47-3

Formula: C4-H7-CL

Synonyms/Common Names:

  • 3-CHLORO-2-METHYL-1-PROPENE

Known Uses:

FUMIGANT. INSECTICIDE. INTERMEDIATE IN PRODUCTION OF PLASTICS, PHARMACEUTICALS, HERBICIDES & PESTICIDES. (TDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54820) Completed 
    • NTIS No. PB86-247293  (Peer Review 11/02/1984)
      Citation: Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CAS No. 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54820) Completed 
    • NTIS No. PB86-247293  (Peer Review 11/02/1984)
      Citation: Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CAS No. 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,50,400, M: 0,125,1250 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C54820) Report Complete 
    • TR-300 (NTIS No. PB86-247293)  (Peer Review 11/02/1984)
      Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CAS No. 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,75,150, M: 0,100,200 MG/KG/50 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0749) Completed 
    • Citation: GHANAYEM, B.I., & BURKA, L.T. COMPARATIVE METABOLSIM AND DISPOSITION OF 1-CHLORO- AND 3-CHLORO-2- METHYLPROPENE IN RATS AND MICE, DRUG METABOLISM AND DISPOSITION, VOL 15, N0 1, 91-96, 1987
    • M Rats: F344/N; M Mice: B6C3F1
  • Cell Proliferation  (S0759) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMICALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
    • M Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (223649) Completed 
    • Mice
    • Chromosome Aberation  Positive 
  • Chromosome Aberrations  (876278) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (087115) Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (164107) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (563589) Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    •  Positive 
  • Micronucleus  (249137) Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (154361) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (701637) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (933790) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (223649) Completed 
    • Mice
    • Sister Chromatid  Positive 
  • Sister Chromatid Exchanges  (876278) Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

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Web page last updated on January 22, 2009