National Toxicology Program

CASRN: 504-88-1

Formula: C3-H5-N-O4

Synonyms/Common Names:

• BETA-NITROPROPANOIC ACID

Known Uses:

NATURALLY OCCURRING; FOOD CONTAMINANT

Short-Term Toxicity

• 13-WEEK (Gavage)  (C03076) Completed 
  • NTIS No. PB281102  (Peer Review 01/18/1978)
    Citation: Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CAS No. 504-88-1)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,100,900, M: 0,150,800 MG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C03076) Report Complete 
  • TR-052 (NTIS No. PB281102)  (Peer Review 01/18/1978)
    Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CAS No. 504-88-1)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,.425,.85, FR: 0,.6,1.2, M: 0,.375,.75 MG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (892866) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma (NCI)  (G46070) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G63977) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9198) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (290153) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive