Testing Status of Agents at NTP
Lithocholic acid
CASRN: 434-13-9
Formula: C24 H40 O3
Synonyms/Common Names:
- (3ALPHA,5BETA)-3-HYDROXY-CHOLAN-24-OIC ACID (9CI)
Known Uses:
BIOLOGICAL RESEARCH CHEMICAL FOUND IN HUMAN & OX BILE (MERCK 1989)
Short-Term Toxicity
- 14-Day (Gavage)
(C03861) Completed
- NTIS No. PB288476
(Peer Review 08/31/1978)
Citation: Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB288476
(Peer Review 08/31/1978)
- 13-Week (Gavage)
(C03861) Completed
- NTIS No. PB288476
(Peer Review 08/31/1978)
Citation: Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,464,2150 MG/KG/5 PER GROUP
- NTIS No. PB288476
(Peer Review 08/31/1978)
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C03861) Report Complete
- TR-175 (NTIS No. PB288476)
(Peer Review 08/31/1978)
Bioassay of Lithocholic Acid for Possible Carcinogenicity (CAS No. 434-13-9) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,250,500, M: 0,125,250 MG/KG/50 PER GROUP
- TR-175 (NTIS No. PB288476)
(Peer Review 08/31/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(963393) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Mouse Lymphoma (NCI)
(G56739) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G78265) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Negative
- Mouse Lymphoma
(244935) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Positive
- Salmonella (NCI)
(N-9253) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(486118) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on January 22, 2009