National Toxicology Program

CASRN: 366-70-1

Formula: C12-H19-N3-O.CL-H

Synonyms/Common Names:

• N-(1-METHYLETHYL)-4-((2-METHYLHYDRAZINO)BENZAMIDE MONOHYDROCHLORIDE (9CI)
• NATULAN HYDROCHLORIDE

Known Uses:

ANTINEOPLASTIC

Short-Term Toxicity

• 14-Day (Intraperitoneal Injection)  (C01810A) Completed 
  •   (Peer Review 07/25/1977) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
  • Rats: Sprague Dawley; Mice: Swiss
• 14-Day (Intraperitoneal Injection)  (C01810B) Completed 
  • NTIS No. PB299902  (Peer Review NA)
    Citation: Bioassay of Procarbazine for Possible Carcinogenicity (CAS No. 366-70-1)
  • Rats: Sprague Dawley; Mice: B6C3F1
• 13-Week (Intraperitoneal Injection)  (C01810A) Completed 
  •   (Peer Review 07/25/1977) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
  • Rats: Sprague Dawley; Mice: Swiss
• 13-Week (Intraperitoneal Injection)  (C01810B) Completed 
  • NTIS No. PB299902  (Peer Review NA)
    Citation: Bioassay of Procarbazine for Possible Carcinogenicity (CAS No. 366-70-1)
  • Rats: Sprague Dawley; Mice: B6C3F1

Long-Term Carcinogenicity

• 2-Year (Intraperitoneal Injection)  (C01810A) Report Complete 
  •   (Peer Review 07/25/1977) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
  • Rats: Sprague Dawley; Mice: Swiss
• 2-Year (Intraperitoneal Injection)  (C01810B) Report Complete 
  • TR-019 (NTIS No. PB299902)  (Peer Review NA)
    Bioassay of Procarbazine for Possible Carcinogenicity (CAS No. 366-70-1)
  • Rats: Sprague Dawley; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,15,30, M: 0,6,12 MG/KG/35 PER GROUP

Genetic Toxicology

• Mouse Lymphoma (NCI)  (G11149) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G78218) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9039) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (557891) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative