National Toxicology Program

CASRN: 302-17-0

Related: CHLORAL 75-87-6

Formula: C2-H3-CL3-O2

Synonyms/Common Names:

• CHLORALDURAT
• LORINAL
• NOCTEC
• 2,2,2-TRICHBRO-1,1-ETHANEDIOL (9CI)
• TRICHLOROACETALDEHYDE MONOHYDRATE

Known Uses:

MEDICATION: CNS DEPRESSANT & SEDATIVE AGENT; IN LINIMENTS; USED IN PEDIATRICS; INTERMEDIATE IN PLASTICS, PESTICIDES. ALSO FOUND IN DRINKING WATER AS RESULT OF CHLORINATION.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Gavage)  (C92010B) Completed 
  • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
• 2-WEEK (Gavage)  (C92010) Completed 
  • NTIS No. PB2002-105712  (Peer Review 05/18/2000)
    Citation: Toxicology and Carcinogenesis Studies of Chloral Hydrate (CAS No. 302-17-0) in B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Dose: R&M: 0, 50, 100, 200, 400, OR 800 MG/KG; 8/GROUP/SEX/SPECIES

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C92010C) Report Complete 
  • TR-503 (NTIS No. PB2003-103039)  (Peer Review 05/18/2000)
    Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CAS No. 302-17-0) in Male B6C3F1 Mice (Gavage Study)
  • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Carcinogenesis Results
  • Male Mice Some Evidence 
  • Dose: 0, 25, 50, OR 100 MG/KG
• 2-YEAR (Gavage)  (C92010) Report Complete 
  • TR-502 (NTIS No. PB2002-105712)  (Peer Review 05/18/2000)
    Toxicology and Carcinogenesis Studies of Chloral Hydrate (CAS No. 302-17-0) in B6C3F1 Mice (Gavage Studies)
  • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • Carcinogenesis Results
  • Female Mice Equivocal Evidence 
  • Dose: 0, 25, 50, OR 100 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (043571) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (852155) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Micronucleus  (518954) Completed 
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (780474) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive 

Organ Systems Toxicity

• SINGLE Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98034) Completed 
  • F Mice: SEC/E X C57B1/E
  • Dose: 400 MG/KG