Testing Status of Agents at NTP
Methyl parathion
CASRN: 298-00-0
Formula: C8-H10-N-O5-P-S
Synonyms/Common Names:
- O,O-DIMETHYLPHOSPHOROTHOIC ACID-O-(4-NITROPHENYL)ESTER (9CI)
Known Uses:
INSECTICIDE
Short-Term Toxicity
- 13-WEEK (Dosed-Feed)
(C02971) Completed
- NTIS No. PB295891
(Peer Review 12/15/1978)
Citation: Bioassay of Methyl Parathion for Possible Carcinogenicity (CAS No. 298-00-0) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,10,50, M: 0,20,500 PPM/5 PER GROUP
- NTIS No. PB295891
(Peer Review 12/15/1978)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C02971) Report Complete
- TR-157 (NTIS No. PB295891)
(Peer Review 12/15/1978)
Bioassay of Methyl Parathion for Possible Carcinogenicity (CAS No. 298-00-0) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,20,40, MM: 0,35,77 (AVG), FM: 0,62.5,125 PPM/50 PER GROUP
- TR-157 (NTIS No. PB295891)
(Peer Review 12/15/1978)
Special Studies
- C. elegans
(S0903) Completed
- Nematode: C. elegans
- Dose: feed: (0,.002,.0032,.005,.0079,.013,.02,.032,.05,.079,.13,.2) mM 2/19/06; repro: (0,.004,.005,.0063,.0079,.01,.013,.02,.025,.032,.04) mM 02/24/06 growth: (0,1,1.6,2.5,4,6.3,10,16,25,40,63,100) uM 07/09/07
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(433667) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Salmonella
(049060) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Web page last updated on January 22, 2009