National Toxicology Program

CASRN: 156-10-5

Formula: C12-H10-N2-O

Synonyms/Common Names:

• 4-NITROSO-N-PHENYLBENZENAMINE (9CI)

Known Uses:

ACCELERATOR IN RUBBER VULCANIZATION, INTERM. FOR DYES & DRUGS, INHIBITOR OF STYRENE-TYPE POLYMERIZATION (HSDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02244) Completed 
  • NTIS No. PB291500  (Peer Review 10/25/1978)
    Citation: Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CAS No. 156-10-5)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02244) Completed 
  • NTIS No. PB291500  (Peer Review 10/25/1978)
    Citation: Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CAS No. 156-10-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,6800,31530, M: 0,1180,25520 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02244) Report Complete 
  • TR-190 (NTIS No. PB291500)  (Peer Review 10/25/1978)
    Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CAS No. 156-10-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Negative 
  • Dose: R: 0,2500,5000, M: 0,4254,9000 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (976337) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (707024) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma (NCI)  (722133) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (986345) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Salmonella  (315639) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Weakly Positive