National Toxicology Program

CASRN: 148-24-3

Related: 8-HYDROXYQUINOLINE SULFATE 134-31-6; TRANSGENIC MODEL EVALUATION (8-HYD

Formula: C9-H7-N-O

Synonyms/Common Names:

• HYDROXYBENZOPYRIDINE
• OXINE
• 8-QUINOLINOL

Known Uses:

REAGENT, ANTIMICROBIAL, PRESERVATIVE, CHEMICAL INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55298) Completed 
  • NTIS No. PB85-213361  (Peer Review 03/23/1984)
    Citation: Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55298) Completed 
  • NTIS No. PB85-213361  (Peer Review 03/23/1984)
    Citation: Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,800,12000, M: 0,400,6000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C55298) Report Complete 
  • TR-276 (NTIS No. PB85-213361)  (Peer Review 03/23/1984)
    Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No. 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0,1500,3000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (470651) Completed 
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (592699) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (616445) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (312315) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (980523) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Positive 
• Micronucleus  (375977) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (073796) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (470651) Completed 
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Mice
  • Sister Chromatid  Negative