National Toxicology Program

CASRN: 148-18-5

Formula: C5-H11-N-S2.NA (TSCAIN) - C5-H10-N-NA-S2

Synonyms/Common Names:

• DIETHYLCARBAMODITHIOIC ACID SODIUM SALT (9CI)

Known Uses:

ANALYSIS OF METALS, TREATMENT FOR METAL POISONING & WILSON'S DISEASE, INTERMED. IN FUNGICIDE & RUBBER PRODUCTION (HSDB 1990)

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C02835) Completed 
  • NTIS No. PB293833  (Peer Review 12/13/1978)
    Citation: Bioassay of Sodium Diethyldithiocarbamate for Possible Carcinogenicity (CAS No. 148-18-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,1250,40000, M: 0,2500,10000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02835) Report Complete 
  • TR-172 (NTIS No. PB293833)  (Peer Review 12/13/1978)
    Bioassay of Sodium Diethyldithiocarbamate for Possible Carcinogenicity (CAS No. 148-18-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,1250,2500, M: 0,500,4000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (552900) Completed 
  • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (456551) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Salmonella  (965008) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative