Testing Information

Testing Status of Agents at NTP

Ethyl acrylate

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http://ntp.niehs.nih.gov/go/TS-10594-X

CASRN: 140-88-5

Formula: C5-H8-O2

Synonyms/Common Names:

  • 2-PROPENOIC ACID, ETHYL ESTER (9CI)

Known Uses:

PRODUCTION OF PAINTS, PAPER AND FABRICS; INGREDIENT IN FLAVORING AND FRAGRANCE

Short-Term Toxicity

  • 14-Day (Gavage)  (C50384) Completed 
    • NTIS No. PB87-204061  (Peer Review 02/28/1983)
      Citation: Carcinogenesis Studies of Ethyl Acrylate (CAS No. 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C50384) Completed 
    • NTIS No. PB87-204061  (Peer Review 02/28/1983)
      Citation: Carcinogenesis Studies of Ethyl Acrylate (CAS No. 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,7,110, M: 0,12,100 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 107-WEEK (Gavage)  (C50384) Report Complete 
    • TR-259 (NTIS No. PB87-204061)  (Peer Review 02/28/1983)
      Carcinogenesis Studies of Ethyl Acrylate (CAS No. 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,100,200 MG/KG/50 PER GROUP
  • 2-YEAR (Gavage)  (C50384) Report Complete 
    • TR-259 (NTIS No. PB87-204061)  (Peer Review 02/28/1983)
      Carcinogenesis Studies of Ethyl Acrylate (CAS No. 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
    • Dose: 0,100,200 MG/KG/50 PER GROUP

Special Studies

  • Cell Proliferation (Gavage)  (S0287) Completed 
    • Citation: GHANAYEM,ET.AL., SUSTAINABILITY OF FORESTOMACH HYPERPLASIA IN RATS TREATED WITH ETHYL ACRYLATE FOR 13 WEEKS & REGRESSION AFTER CESSATIONOF DOSING, TOXICOL PATH 19(3):273-279,1991
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Cell Proliferation (Gavage)  (S0368) Completed 
    • Citation: GHANAYEM, ET.AL., ROLE OF CHEMICALLY INDUCED CELL PROLIFERATION IN EA-INDUCED FORESTOMACH CARCINOGENESIS, CHEM INDUCED CELL PROL:IMPLIC FOR RISK ASSESS, PP337-346,1991
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Cell Proliferation (Gavage)  (S0746) Completed 
    • Citation: GHANAYEN, B.I., MARONPOT, R.R., & MATTHEWS, H.B. ETHYL ACRYLATE-INDUCED GASTRIC TOXICITY I, EFFECT OF SINGLE AND REPETITIVE DOSING. TOXICOLOGY AND APPLIED PHARMACOLOGY 80, 323-335 (1985)
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Cell Proliferation (Gavage)  (S0747) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R., & MATTHEWS, H.B. ETHYL ACRYLATE-INDUCED GASTRIC TOXICITY III. DEVELOPMENT AND RECOVERY OF LESIONS TOXICOLOGY AND APPLIED PHARMACOLOGY 83, 576-583, (1986)
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Cell Proliferation (Gavage)  (S0748) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R., & MATTHEWS, H.B. EFFECTS OF SULFHYDRYL MODULATION ON ETHYL ACRYLATE-INDUCED FORESTOMACH TOXICITY TOXICOOGY LETTERS, 55 (1991) 215-221
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Cell Proliferation (Gavage)  (S0757) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMICALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
    • M Rats: F344/N
  • Mechanisms (Gavage)  (S0467) Completed 
    • Citation: GHANAYEM, ET.AL., ETHYL ACRYLATE-INDUCED GASTRIC TOXICITY: II. STRUCTURE-TOXICITY RELATIONSHIPS & MECHANISM, TOXICOL & APPL PHARM 80:336-344,1985.
    • M Rats: F344/N
  • Metabolism (Gavage)  (S0369) Completed 
    • Citation: GHANAYEM, B.I., BURKA, L.T. & MATTHEWS, H.B.: ETHYL ACRYLATE DISTRIBUTION, MACROMOLECULAR BINDING, EXCRETION, AND METABOLISM IN THE MALE FISHER 344 RATS, 9:389-397, 1987.
    • M Rats: F344/N
    • Dose: 100, 200, 400 mg/kg
  • Metabolism  (S0780) Completed 
    • Citation: METABOLISM OF ETHYL ACRYLATE IN THE STOMACHS OF MALE AND FEMALE FISCHER 344 RATS (1982)
    • M/F Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (272157) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (402439) Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Weakly Positive 
  • In Vitro Cytogenetics (CA/SCE)  (550589) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (177932) Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (518545) Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (270996) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella  (324746) Completed 
    •  Negative 
  • Salmonella  (623002) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (749805) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (840926) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (272157) Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • 4 DAY, 8 DAY Immunotoxicity (Topical Application)  (IMM95004) Completed 
    • F Mice: B6C3F1
    • Dose: 10, 20, AND 30% IN ACETONE (99.8%) FOR SENSITIZATION AND 30% FOR CHALLENGE; 0.25% DNFB AS POSITIVE CONTROL AND 0.5% FOR CHALLENGE

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Web page last updated on January 22, 2009