National Toxicology Program

CASRN: 140-49-8

Formula: C10 H10 CL N O2

Synonyms/Common Names:

• N-(4-CHLOROACETYL)PHENYL)-ACETAMIDE (9CI)

Known Uses:

AZO DYE INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03770) Completed 
  • NTIS No. PB288754  (Peer Review 08/31/1978)
    Citation: Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CAS No. 140-49-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03770) Completed 
  • NTIS No. PB288754  (Peer Review 08/31/1978)
    Citation: Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CAS No. 140-49-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,1000,21500, M: 0,2150,21500 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03770) Report Complete 
  • TR-177 (NTIS No. PB288754)  (Peer Review 08/31/1978)
    Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CAS No. 140-49-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,1000,2000, M: 0,5000,10000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (223043) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9228) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (468840) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive