Testing Information

Testing Status of Agents at NTP

Benzyl acetate

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http://ntp.niehs.nih.gov/go/TS-10591-K

CASRN: 140-11-4

Formula: C9-H10-O2

Synonyms/Common Names:

  • ACETIC ACID, PHENYLMETHYL ESTER (9CI)

Known Uses:

SOAP FRAGRANCE; FLAVORING INGREDIENT; SOLVENT FOR CELLULOSE ACETATE AND CELLULOSE NITRATE

Short-Term Toxicity

  • 14-Day (Gavage)  (C06508A) Completed 
    • NTIS No. PB87-115044  (Peer Review 11/02/1984)
      Citation: Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C06508A) Completed 
    • NTIS No. PB87-115044  (Peer Review 11/02/1984)
      Citation: Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&MM: 0,62.5,1000, FM: 0,125,2000 MG/KG/10 PER GROUP
  • 13-WEEK (Dosed-Feed)  (C06508B) Completed 
    • NTIS No. PB94-184033  (Peer Review 12/01/1992)
      Citation: Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&MM: 0,62.5,1000, FM: 0,125,2000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C06508A) Report Complete 
    • TR-250 (NTIS No. PB87-115044)  (Peer Review 11/02/1984)
      Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP
  • 2-YEAR (Dosed-Feed)  (C06508B) Report Complete 
    • TR-431 (NTIS No. PB94-184033)  (Peer Review 12/01/1992)
      Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,0.3,0.6,1.2%, M: 0,0.033,0.1,0.3%/50 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Intravenous; Gavage)  (S0072) Completed 
    • Citation: ABDO ET AL. BENZYL ACETATE CARCINOGENICITY, METABOLISM, AND DISPOSITION IN FISCHER 344 RATS AND B6C3F1 MICE. TOXICOLOGY 37:159-170, 1985
    • M/F Rats: F344/N; M/F Rats: F344/N; M/F Mice; M/F Mice
    • Dose: R/PO:25,500;M/PO:500,1000;R/IV:5;M/IV:10MG/KG
  • Absorption Disposition Metabolism Elimination  (S0441) Completed 
    • Citation: MCMAHON, T.F., DILIBERTO, J.J. & BIRNBAUM, L.S., AGE-RELATED CHANGES IN THE DISPOSITION OF BENZYL ACETATE, DRUG MET & DISP 17(5):506-512, 1989.
    • M Rats: F344/N; M Mice: C57BL/6
  • Toxicokinetic Study (Gavage; Dosed-Feed)  (S0319) Completed 
    • Citation: YUAN, J.H., GOEHL, T.G., ABDO, K., CLARK, J., ESPINOSA, O. BUGGE, C.& GARCIA, D. - EFFECTS OF GAVAGE VERSUS DOSED FEED ADMINISTRATION ON THE TOXICOKINETICS OF BENZYL ACETATE IN RATS AND MICE - FD CHEM. TOXIC. VOL.(33) PP. 151-158, 1995
    • M Rats: F344/N; M Mice: B6C3F1; M Rats: F344/N; M Mice: B6C3F1
    • Dose: GAVAGE - 500 MG/KG (RAT) AND 1000 MG/KG (MICE) FEED - 10,800 PPM (RATS) AND 2700 PPM (MICE)

Genetic Toxicology

  • Chromosome Aberrations  (500814) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (453123) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Drosophila  (034451) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (311211) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Mouse Lymphoma  (351266) Completed 
    •  Positive 
  • Micronucleus  (432849) Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A89285) Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (883303) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (500814) Completed 
    • Mice
    • Sister Chromatid  Negative 

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Web page last updated on January 22, 2009