National Toxicology Program

CASRN: 137-30-4

Formula: C6 H12 N2 S4 ZN

Synonyms/Common Names:

• (T-4)-BIS(DIMETHYLCARBAMODITHIOATO-S,S')ZINC (9CI)

Known Uses:

FUNGICIDE & ACCELERATOR IN RUBBER VULCANIZATION

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C50442) Completed 
  • NTIS No. PB83-202622  (Peer Review 12/16/1981)
    Citation: Carcinogenesis Bioassay of Ziram (CAS No. 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C50442) Completed 
  • NTIS No. PB83-202622  (Peer Review 12/16/1981)
    Citation: Carcinogenesis Bioassay of Ziram (CAS No. 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 300, 600, 1200, 2500, OR 5000 PPM

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C50442) Report Complete 
  • TR-238 (NTIS No. PB83-202622)  (Peer Review 12/16/1981)
    Carcinogenesis Bioassay of Ziram (CAS No. 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Equivocal 
  • Dose: R: 0, 300, OR 600 PPM M: 0, 600, OR 1200 PPM

Genetic Toxicology

• Chromosome Aberrations  (880520) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (054163) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• Drosophila  (075511) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (746976) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (356540) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive 
• Sister Chromatid Exchanges  (880520) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)