Testing Information

Testing Status of Agents at NTP

4-Hexylresorcinol

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http://ntp.niehs.nih.gov/go/TS-10588-F

CASRN: 136-77-6

Formula: C12-H18-O2

Synonyms/Common Names:

  • 4-HEXYL-1,3-BENZENEDIOL (9CI)

Known Uses:

ANTHELMINTIC, TOPICAL ANTISEPTIC

Short-Term Toxicity

  • 14-Day (Gavage)  (C55787) Completed 
    • NTIS No. PB89-128607  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55787) Completed 
    • NTIS No. PB89-128607  (Peer Review 03/04/1987)
      Citation: Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,62.5,1000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C55787) Report Complete 
    • TR-330 (NTIS No. PB89-128607)  (Peer Review 03/04/1987)
      Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0,62.5,125 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (813308) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (356349) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Micronucleus  (A25951) Completed 
    • Rats: F344
    • Male Negative 
  • Micronucleus  (A27137) Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (267489) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (948583) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

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Web page last updated on January 22, 2009