Testing Status of Agents at NTP
Phenazopyridine hydrochloride
CASRN: 136-40-3
Formula: C11-H11-N5.CL-H
Synonyms/Common Names:
- 3-(PHENYLAZO)-2,6-PYRIDINEDIAMINE MONOHYDROCHLORIDE (9CI)
- PYRIDIUM
Known Uses:
URINARY ANALGESIC (MERCK 1989); AZO DYE
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01672) Completed
- NTIS No. PB286207
(Peer Review 04/26/1978)
Citation: Bioassay of Phenazopyridine Hydrochloride for Possible Carcinogenicity (CAS No. 136-40-3) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB286207
(Peer Review 04/26/1978)
- 13-Week (Dosed-Feed)
(C01672) Completed
- NTIS No. PB286207
(Peer Review 04/26/1978)
Citation: Bioassay of Phenazopyridine Hydrochloride for Possible Carcinogenicity (CAS No. 136-40-3) - Rats: F344/N; Mice: B6C3F1
- Dose: MR: 0,300,6000, FR: 0,7500,15000, M:0,500,10000 PPM/5 PER GROUP
- NTIS No. PB286207
(Peer Review 04/26/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01672) Report Complete
- TR-099 (NTIS No. PB286207)
(Peer Review 04/26/1978)
Bioassay of Phenazopyridine Hydrochloride for Possible Carcinogenicity (CAS No. 136-40-3) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Positive
- Dose: R: 0,3700,7500, M: 0,600,1200 PPM/35 PER GROUP
- TR-099 (NTIS No. PB286207)
(Peer Review 04/26/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(693896) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(229192) Completed
- Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
- Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive
- Drosophila
(513664) Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive
- Mouse Lymphoma
(051415) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Positive
- Salmonella
(052770) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Inconclusive
- Salmonella
(945906) Completed
- Positive
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