National Toxicology Program

CASRN: 135-88-6

Formula: C16-H13-N

Synonyms/Common Names:

• N-PHENYL-2-NAPHTHALENAMINE (9CI)

Known Uses:

RUBBER ANTIOXIDANT. LUBRICANT. CATALYST. IN DYES, SURGICAL PLASTERS. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02915) Completed 
  • NTIS No. PB88-216270  (Peer Review 03/04/1987)
    Citation: Toxicology and Carcinogenesis Studies of N-Phenyl-2-naphthylamine (CAS No. 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02915) Completed 
  • NTIS No. PB88-216270  (Peer Review 03/04/1987)
    Citation: Toxicology and Carcinogenesis Studies of N-Phenyl-2-naphthylamine (CAS No. 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,2500,45000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 108-WEEK (Dosed-Feed)  (C02915) Report Complete 
  • TR-333 (NTIS No. PB88-216270)  (Peer Review 03/04/1987)
    Toxicology and Carcinogenesis Studies of N-Phenyl-2-naphthylamine (CAS No. 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Equivocal Evidence 
  • Dose: 0,2500,5000 PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0216) Completed 
  • M Rats: F344/N
  • Dose: 0.465 & 0.216% X 8 DAYS

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (796411) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Mouse Lymphoma  (945201) Completed 
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Salmonella  (585564) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative