National Toxicology Program

CASRN: 135-20-6

Formula: C6 H6 N2 O2.H3 N

Synonyms/Common Names:

• N-NITROSOPHENYLHYDROXYLAMINE AMMONIUM SALT (9CI)

Known Uses:

LABORATORY REAGENT, USED TO SEPARATE TIN FROM ZINC, COPPER AND IRON

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03258) Completed 
  • NTIS No. PB287409  (Peer Review 06/29/1978)
    Citation: Bioassay of Cupferron for Possible Carcinogenicity (CAS No. 135-20-6)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03258) Completed 
  • NTIS No. PB287409  (Peer Review 06/29/1978)
    Citation: Bioassay of Cupferron for Possible Carcinogenicity (CAS No. 135-20-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.02,.30, M: 0,.04,.60 %/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03258) Report Complete 
  • TR-100 (NTIS No. PB287409)  (Peer Review 06/29/1978)
    Bioassay of Cupferron for Possible Carcinogenicity (CAS No. 135-20-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,.15,.30 M: 0,.2,.4 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (705717) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9405) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (353732) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive