National Toxicology Program

CASRN: 134-72-5

Formula: C10-H15-N-O.1/2H2-O4-S

Synonyms/Common Names:

• ALPHA-(1-(METHYLAMINO)ETHYL)BENZENEMETHANOL, (R-(R*,S*))-, SULFATE(2:1)(SALT) (9CI)

Known Uses:

MEDICINE (BRONCHODILATOR). VETERINARY MEDICINE AS A MYDRIATIC AND SYMPATHOMIMETIC IN ALLERGIC REACTIONS. CNS STIMULANT.(1,2)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55652) Completed 
  • NTIS No. PB86-247285  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55652) Completed 
  • NTIS No. PB86-247285  (Peer Review 08/14/1985)
    Citation: Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,125,2000, M: 0,310,5000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C55652) Report Complete 
  • TR-307 (NTIS No. PB86-247285)  (Peer Review 08/14/1985)
    Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0,125,250 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (627991) Completed 
  • Chromosome Aberation Not Tested 
  • Sister Chromatid Exchange Weakly Positive 
• In Vitro Cytogenetics (CA/SCE)  (932450) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (873748) Completed 
  •  Negative 
• Salmonella  (232351) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative