Testing Status of Agents at NTP
o-Anisidine hydrochloride
CASRN: 134-29-2
Related: O-ANISIDINE (90-04-0)
Formula: C7 H9 N O.CL H
Synonyms/Common Names:
- 2-METHOXYBENZENAMINE HYDROCHLORIDE (9CI)
Known Uses:
MANUFACTURE OF AZO DYES; FORMERLY LISTED AS POSSIBLE INGREDIENT IN PERMANENT OXIDATION HAIR DYES (NO LONGER USED IN THE US)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03747) Completed
- NTIS No. PB285879
(Peer Review 04/26/1978)
Citation: Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB285879
(Peer Review 04/26/1978)
- 13-Week (Dosed-Feed)
(C03747) Completed
- NTIS No. PB285879
(Peer Review 04/26/1978)
Citation: Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,1000,30000 PPM/5 PER GROUP
- NTIS No. PB285879
(Peer Review 04/26/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03747) Report Complete
- TR-089 (NTIS No. PB285879)
(Peer Review 04/26/1978)
Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 134-29-2) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R: 0,5000,10000, M: 0,2500,5000 PPM/55 PER GROUP
- TR-089 (NTIS No. PB285879)
(Peer Review 04/26/1978)
Genetic Toxicology
- Micronucleus
(563139) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella (NCI)
(N-9366) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
Web page last updated on January 22, 2009