Testing Information

Testing Status of Agents at NTP

Penicillin VK

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10581-D

CASRN: 132-98-9

Formula: C16-H18-N2-O5-S.K

Synonyms/Common Names:

  • (2S-(2ALPHA,5ALPHA,6BETA))-3,3-DIMETHYL-7-OXO-6((PHENOXYACETYL)AMINO)-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID MONOPOTASSIUM SALT (9CI)

Known Uses:

ANTIBIOTIC

Short-Term Toxicity

  • 14-Day (Gavage)  (C56100) Completed 
    • NTIS No. PB89-128615  (Peer Review 07/14/1987)
      Citation: Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56100) Completed 
    • NTIS No. PB89-128615  (Peer Review 07/14/1987)
      Citation: Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,180,3000 M: 0,250,3000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C56100) Report Complete 
    • TR-336 (NTIS No. PB89-128615)  (Peer Review 07/14/1987)
      Toxicology and Carcinogenesis Studies of Penicillin VK (CAS No. 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0,500,1000 MG/KG/ 50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (130786) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Not Tested 
  • In Vitro Cytogenetics (CA/SCE)  (391874) Completed 
    • Chromosome Aberation Not Tested 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma (NCI)  (698417) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (954196) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Salmonella  (688328) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Back to top

Web page last updated on January 22, 2009