Testing Information

Testing Status of Agents at NTP

C.I. Vat yellow 4

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http://ntp.niehs.nih.gov/go/TS-10576-P

CASRN: 128-66-5

Formula: C24-H12-O2

Synonyms/Common Names:

  • DIBENZO(B,DEF)CHRYSENE-7,14-DIONE
  • YELLOW 4, C.I. VAT

Known Uses:

DYE FOR CELLULOSE FIBERS AND SYNTHETICS, WOOL, SILK; PIGMENT FOR PAPER; MILITARY SMOKE DYE

Short-Term Toxicity

  • 13-WEEK (Dosed-Feed)  (C03565) Completed 
    • NTIS No. PB288821  (Peer Review 08/31/1978)
      Citation: Bioassay of C.I. Vat Yellow 4 for Possible Carcinogenicity (CAS No. 128-66-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,6200,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C03565) Report Complete 
    • TR-134 (NTIS No. PB288821)  (Peer Review 08/31/1978)
      Bioassay of C.I. Vat Yellow 4 for Possible Carcinogenicity (CAS No. 128-66-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Negative 
    • Dose: R: 0,3500,7000, MM: 0,25000,50000, FM: 0,12500,25000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (876338) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (350442) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 
  • Salmonella  (897779) Completed 
    •  Negative 

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Web page last updated on January 22, 2009