National Toxicology Program

CASRN: 124-48-1

Formula: C-H-BR2-CL

Synonyms/Common Names:

• DIBROMOCHLOROMETHANE

Known Uses:

ORGANIC SYNTHESIS. LAB CHEMICAL.(TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C55254) Completed 
  • NTIS No. PB86-166675  (Peer Review 03/23/1984)
    Citation: Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55254) Completed 
  • NTIS No. PB86-166675  (Peer Review 03/23/1984)
    Citation: Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,15,25 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C55254) Report Complete 
  • TR-282 (NTIS No. PB86-166675)  (Peer Review 03/23/1984)
    Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0,40,80, M: 0,50,100 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (687058) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (096876) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (261721) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (558894) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (988921) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Micronucleus  (306321) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (065376) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 
• Salmonella  (A32951) Completed 
  •  Weakly Positive 
• Sister Chromatid Exchanges  (687058) Completed 
  • Mice
  • Sister Chromatid  Negative 

Organ Systems Toxicity

• 28 DAYS Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94003) Completed 
  • NTIS No. PB97-111728
    Citation: Short Term Reproductive and Developmental Toxicity of Chlorodibromomethane (CAS #124-48-1) Administered in Drinking Water to Sprague-Dawley Rats
  • M/F Rats: Sprague Dawley
  • Dose: 0, 50, 150, OR 450 PPM