Testing Status of Agents at NTP
Chlorodibromomethane
CASRN: 124-48-1
Formula: C-H-BR2-CL
Synonyms/Common Names:
- DIBROMOCHLOROMETHANE
Known Uses:
ORGANIC SYNTHESIS. LAB CHEMICAL.(TDB)
Short-Term Toxicity
- 14-Day (Gavage)
(C55254) Completed
- NTIS No. PB86-166675
(Peer Review 03/23/1984)
Citation: Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB86-166675
(Peer Review 03/23/1984)
- 13-Week (Gavage)
(C55254) Completed
- NTIS No. PB86-166675
(Peer Review 03/23/1984)
Citation: Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,15,25 MG/KG/10 PER GROUP
- NTIS No. PB86-166675
(Peer Review 03/23/1984)
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C55254) Report Complete
- TR-282 (NTIS No. PB86-166675)
(Peer Review 03/23/1984)
Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CAS No. 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice Equivocal Evidence
- Female Mice Some Evidence
- Dose: R: 0,40,80, M: 0,50,100 MG/KG/50 PER GROUP
- TR-282 (NTIS No. PB86-166675)
(Peer Review 03/23/1984)
Genetic Toxicology
- Chromosome Aberrations
(687058) Completed
- Mice
- Chromosome Aberation Positive
- In Vitro Cytogenetics (CA/SCE)
(096876) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- In Vitro Cytogenetics (CA/SCE)
(261721) Completed
- Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Drosophila
(558894) Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(988921) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Positive
- Micronucleus
(306321) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(065376) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Negative
- Salmonella
(A32951) Completed
- Weakly Positive
- Sister Chromatid Exchanges
(687058) Completed
- Mice
- Sister Chromatid Negative
Organ Systems Toxicity
- 28 DAYS Repro/Dev Gen Tox (28-Day) (Dosed-Water)
(RDGT94003) Completed
- NTIS No. PB97-111728
Citation: Short Term Reproductive and Developmental Toxicity of Chlorodibromomethane (CAS #124-48-1) Administered in Drinking Water to Sprague-Dawley Rats - M/F Rats: Sprague Dawley
- Dose: 0, 50, 150, OR 450 PPM
- NTIS No. PB97-111728
Web page last updated on January 22, 2009