Testing Status of Agents at NTP
p-Cresidine
CASRN: 120-71-8
Related: M-CRESIDINE (CAS 102-50-1)
Formula: C8-H11-N-O
Synonyms/Common Names:
- 2-METHOXY-5-METHYLBENZENAMINE
Known Uses:
CHEMICAL INTERMEDIATE FOR DYES. (TDB)
Short-Term Toxicity
- 2-WEEK (Dosed-Feed)
(C02982B) Completed
- Mice: MMTV/RAS (Tg.SH); Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk)
- Dose: 0, 2500, 5000, 10000, OR 20000 PPM
- 14-Day (Dosed-Feed)
(C02982) Completed
- NTIS No. PB295835
(Peer Review 06/29/1978)
Citation: Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB295835
(Peer Review 06/29/1978)
- 13-Week (Dosed-Feed)
(C02982) Completed
- NTIS No. PB295835
(Peer Review 06/29/1978)
Citation: Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,.02,.3, M: 0,.04,.6 %/10 PER GROUP
- NTIS No. PB295835
(Peer Review 06/29/1978)
Long-Term Carcinogenicity
- 26&39-WK (Dosed-Feed)
(C02982B) Completed
- Mice: MMTV/RAS (Tg.SH); Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk)
- Dose: 0, 2500, OR 5000 PPM
- 2-Year (Dosed-Feed)
(C02982) Report Complete
- TR-142 (NTIS No. PB295835)
(Peer Review 06/29/1978)
Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R: 0,.5,1.0, MM: 0,.22,.46, FM: 0,.22,.44 %/50 PER GROUP
- TR-142 (NTIS No. PB295835)
(Peer Review 06/29/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(459789) Completed
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Weakly Positive
- Micronucleus
(104686) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella (NCI)
(N-9378) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(496780) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
Web page last updated on January 22, 2009