Testing Information

Testing Status of Agents at NTP

Piperonyl sulfoxide

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http://ntp.niehs.nih.gov/go/TS-10554-R

CASRN: 120-62-7

Formula: C18-H28-O3-S

Synonyms/Common Names:

  • 5-(2-(OCTYLSULFINYL)PROPYL)BENZENE (9CI)

Known Uses:

SYNERGIST IN INSECTICIDES WITH PYRETHRINS

Short-Term Toxicity

  • 13-WEEK (Dosed-Feed)  (C02824) Completed 
    • NTIS No. PB288778  (Peer Review 08/31/1978)
      Citation: Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity (CAS No. 120-62-7)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,4600,21500, M: 0,50,2400 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C02824) Report Complete 
    • TR-124 (NTIS No. PB288778)  (Peer Review 08/31/1978)
      Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity (CAS No. 120-62-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Negative 
    • Dose: MR: 0,1500,3000, FR: 0,3000,6000, MM: 0,350,700, FM: 0,295,754 (AVG) PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (616035) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Drosophila  (552792) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (096915) Completed 
    •  Positive 
  • Salmonella  (914423) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (974757) Completed 
    •  Negative 

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Web page last updated on January 22, 2009