Testing Information

Testing Status of Agents at NTP

4-Amino-2-nitrophenol

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http://ntp.niehs.nih.gov/go/TS-10547-V

CASRN: 119-34-6

Formula: C6 H6 N2 O3

Synonyms/Common Names:

  • O-NITRO-P-AMINOPHENOL

Known Uses:

FORMERLY USED IN PERMANENT HAIR DYE PRODUCTS; FUR DYE

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03963) Completed 
    • NTIS No. PB286189  (Peer Review 04/26/1978)
      Citation: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CAS No. 119-34-6)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03963) Completed 
    • NTIS No. PB286189  (Peer Review 04/26/1978)
      Citation: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CAS No. 119-34-6)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,100,46400, M: 0,147,6810 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03963) Report Complete 
    • TR-094 (NTIS No. PB286189)  (Peer Review 04/26/1978)
      Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CAS No. 119-34-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,1250,2500 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (524919) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma (NCI)  (G61063) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (G81743) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Salmonella (NCI)  (N-9226) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (720733) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 

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Web page last updated on January 22, 2009