National Toxicology Program

CASRN: 117-79-3

Formula: C14 H9 N O2

Synonyms/Common Names:

• 2-AMINO-9,10-ANTHRACENEDIONE (9CI)

Known Uses:

DYE INTERMEDIATE FOR DYES USED IN PAINTS AND OTHER PIGMENTS

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01876) Completed 
  • NTIS No. PB287739  (Peer Review 06/29/1978)
    Citation: Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CAS No. 117-79-3)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01876) Completed 
  • NTIS No. PB287739  (Peer Review 06/29/1978)
    Citation: Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CAS No. 117-79-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1,5 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01876) Report Complete 
  • TR-144 (NTIS No. PB287739)  (Peer Review 06/29/1978)
    Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CAS No. 117-79-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Inadequate Study 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: FR: 0,.2 (AVG), MR: 0,.35,.69 (AVG), M: 0,.5,1.0 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (230007) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9402) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (634899) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive