National Toxicology Program

CASRN: 110-86-1

Formula: C5-H5-N

Synonyms/Common Names:

• AZABENZENE

Known Uses:

SOLVENT, ORGANIC SYNTHESIS, FLAVORING INGREDIENT, MANUFACTURE OF FUNGICIDES, PHARMACEUTICALS, DYESTUFF, EXPLOSIVES, MFR OF VITAMINS, SULFA DRUGS, INTR IN MANUF OF DIQUAT & PARAQUAT, WATERPROOFING TEXTILES (HSDB 1990)

Short-Term Toxicity

• 13-WEEK (Dosed-Water)  (C55301B) Completed 
  • NTIS No. PB2000-106687  (Peer Review 12/10/1997)
    Citation: Toxicology and Carcinogenesis Studies of Pyridine (CAS No. 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: Wistar
  • Dose: R&M: 0, 50, 100, 250, 500, OR 1000 PPM

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C55301B) Report Complete 
  • TR-470 (NTIS No. PB2000-106687)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Pyridine (CAS No. 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: Wistar
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP)
• 2-YEAR (Dosed-Water)  (C55301E) Report Draft 
  • TR-470 (NTIS No. PB2000-106687)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Pyridine (CAS No. 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
  • Rats: Wistar
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 

Special Studies

• Metabolism  (S0716) Completed 
  • Citation: WLKE, T.J., JONDORF, W.R., AND POWIS, G., OXIDATIVE METABOLISM OF 14C-PYRIDINE BY HUMAN AND RAT TISSUE SUBCELLULAR FRACTIONS, XENOBIOTICA, VOL 19, #9, 1013-1022, 1989
  • M Rats: F344/N; Human
• C. elegans  (S0870) Completed 
  • Nematode: C. elegans
  • Dose: feed: (0, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100) 6/4/05 repro: (0, 5, 6.3, 7.9 10, 13, 16, 20, 25, 32, 40, 50) 6/2/05 growth: (0, 2.5, 4.0, 6.3, 10, 16, 25, 50, 63, 100, 160, 250) mM 4/17/06

Genetic Toxicology

• Chromosome Aberrations  (A86776) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (148320) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (631306) Completed 
  • Chromosome Aberation Not Tested 
  • Sister Chromatid Exchange Not Tested 
• Drosophila  (372184) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Drosophila  (383713) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (768654) Completed 
  • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (746434) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Negative 
• Micronucleus  (A16600) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A85799) Completed 
  • Mice: MICE
  • Male Negative 
  • Female Negative 
• Salmonella  (364799) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative