Testing Information

Testing Status of Agents at NTP

bis(2-Chloro-1-methylethyl) ether

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http://ntp.niehs.nih.gov/go/TS-10523-N

CASRN: 108-60-1

Formula: C6-H12-CL2-0

Synonyms/Common Names:

  • BIS(2-CHLOROISOPROPYL)ETHER
  • PROPANE,2,2'-OXYBIS[1-CHLORO- (9CI)

Known Uses:

PAINT & VARNISH REMOVERS; INTERMEDIATE IN DYES, RESINS AND PHARMACEUTICALS; NEMATOCIDE IN JAPAN

Short-Term Toxicity

  • 14-Day (Gavage)  (C50044A) Completed 
    • NTIS No. PB299741  (Peer Review 05/01/1979)
      Citation: Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CAS No. 108-60-1)
    • Rats: F344/N
  • 13-Week (Gavage)  (C50044A) Completed 
    • NTIS No. PB299741  (Peer Review 05/01/1979)
      Citation: Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CAS No. 108-60-1)
    • Rats: F344/N
    • Dose: 0,10,250 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C50044A) Report Complete 
    • TR-191 (NTIS No. PB299741)  (Peer Review 05/01/1979)
      Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CAS No. 108-60-1)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0,100,200 MG/KG/50 PER GROUP
  • 2-Year (Gavage)  (C50044B) Report Complete 
    • TR-239 (NTIS No. PB83-169615)  (Peer Review 12/16/1981)
      Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CAS No. 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CAS No. 83270-31-9) in B6C3F1 Mice (Gavage Study)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,100,200 MG/KG/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (500655) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (453382) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (945998) Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
  • Mouse Lymphoma  (151175) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella  (035504) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Salmonella  (082677) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (175248) Completed 
    •  Positive 
  • Salmonella  (247021) Completed 
    •  Positive 
  • Salmonella  (856126) Completed 
    •  Positive 
  • Salmonella  (891894) Completed 
    •  Positive 
  • Sister Chromatid Exchanges  (500655) Completed 
    • Mice
    • Sister Chromatid  Negative 

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Web page last updated on January 22, 2009