Testing Information

Testing Status of Agents at NTP

1,3-Butadiene

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http://ntp.niehs.nih.gov/go/TS-10514-J

CASRN: 106-99-0

Formula: C4-H6

Synonyms/Common Names:

  • ALPHA,GAMMA-BUTADIENE

Known Uses:

CHEMICAL INTERMEDIATE. MANUFACTURE OF SYNTHETIC RUBBER. PRODUCED FROM PETROLEUM GASES (MERCK 1989)

Short-Term Toxicity

  • 13-WEEK (Inhalation)  (C50602B) Completed 
    • Rats: F344/N
    • Dose: R: 0, 200, 625, 2000, OR 6250 PPM M: 0, 625, 1250, 5000, 8000, OR 16000 PPM

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C50602A) Report Complete 
    • TR-288 (NTIS No. PB85-179646)  (Peer Review 10/28/1983)
      Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0,625,1250 PPM/50 PER GROUP
  • 2-YEAR (Inhalation)  (C50602C) Report Complete 
    • TR-434 (NTIS No. PB94-101631)  (Peer Review 11/21/1991)
      Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0, 6.25, 20, 62.5, 200, 625 PPM/50 PER GROUP
  • 2-YEAR (Inhalation)  (C50602D) Completed 
    • Citation: Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
    • Mice: B6C3F1
    • Dose: MICE ONLY: 0, 1000, 5000, 10000 PPM/60 PER GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0220) Completed 
    • Citation: DAHL, A.R., BECHTOLD, W.E., BOND, J.A., HENDERSON, R.F., MAUDERLY, J.L., MUGGENBURG, B.S., DUN, J.D., AND BIRNBAUM, L.S. SPECIES DIFFERENCES IN THE METABOLISM AND DISPOPSITION OF INHALED 1,3-BUTADIENE AND ISOPRENE. ENVIRONMENTAL HLTH PERSPECTIVES, VOL 86, PP. 65-69, 1990
    • Rats; Mice; Monkey
  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0792) Completed 
    • Citation: BOND, J.A., DAHL, A.R., HENDERSON, R.F., DUTCHER, J.S., MAUDERLLY, J.L., AND BIRNBAUM, L.S. SPECIES DIFFERENCES IN THE DISPOSITION OF INHALED BUTADIENE. TOXICOLOGY AQND APPLIED PHARMACOLOGY 84, 612-627 (1986)
    • M Rats: Sprague Dawley; M Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0793) Completed 
    • Citation: BOND, J.A., MARTIN, O.S., BIRNBAUM, L.S., DAHL, A.R., MELNICK, R.L., AND HENDERSON, R.F. METABOLISM OF 1,3-BUTADIENE BY LUNG AND LIVER MICROSOMES OF RATS AND MICE R EPEATEDLY EXPOSED BY INHALATION TO 1,3-BUTADIENE. TOXICOLOGY LETTERS, 44 (1988) 143-151.
    • M Rats: Sprague Dawley; M Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0794) Completed 
    • Citation: BOND, J.A., DAHL, A.R., HENDERSON, R.F., AND IRNBAUM, L.S. SPECIES DIFFERENCES IN THE DISTRIBUTION OF INHALED BUTADIENE IN TISSUES. AM. IND. HYG. ASSOC. J. (48) 867-872, (1987)
    • M Rats: Sprague Dawley; M Mice: B6C3F1
  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0795) Completed 
    • Citation: SABOURIN, P.J., BURKA, L.T., BECHTOLD, W.E., DAHL, A.R., HOOVER, M.D., CHANG, I.Y., AND HENDERSON, R.F. SPECIES DIFFERENCES IN URINARY BUTADIENE METABOLITES; IDENTIFICATION OF 1,2-DIHYDROXY-4- (N-ACETYLCYSTEINYL) BUTANE, A NOVEL METABOLITE OF BUTADIENE CARCINOGENESIS, VOL 13, NO. 9, PP. 1633-1638, 1992
    • Rats: F344/N; Rats: Sprague Dawley; Hamsters: Syrian Golden; Monkey; Mice: B6C3F1
  • Other (Intraperitoneal Injection)  (S0459) Completed 
    • Citation: BIRNBAUM, ET.AL., CHARACTERIZATION OF HEMOGLOBIN ADDUCT FORMATION IN MICE & RATS AFTER ADMINISTRATION OF [14C]BUTADIENE OR [14C]ISOPRENE, TOXICOL & APPL PHARM 100:86-95,1989.
    • M Rats: Sprague Dawley; M Mice: B6C3F1
    • Dose: 1,10,100 OR 1000 UMOL [14C]BUTADIENE
  • Toxicokinetic Study (Inhalation)  (S0796) Completed 
    • Citation: DAHL, A.R., SUN, J.D., BIRNBAUM, L.S., BOND, J.S., GRIFFITH, W.C. JR, MAUDERLY, J.L., MUGGENBURG, B.S., SABOURIN, P.J., AND HENDERSON, R.F. TOXICOKINETICS OF INHALED 1,3-BUTADIENE IN MONKEYS: COMPARISON TO TOXICOKINETICS OF RATS AND MICE. TOXICOLOGY AND APPLIED PHARMACOLOGY 110, 9-19 (1991)
    • Monkey; Rats; Mice

Genetic Toxicology

  • Chromosome Aberrations  (A74454) Completed 
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Mice
  • Chromosome Aberrations  (A93093) Completed 
    • Mice
    • Chromosome Aberation  Positive 
  • Drosophila  (950073) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (614566) Completed 
    • Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
    •  Negative 
  • Micronucleus  (A74454) Completed 
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Mice: B6C3F1
    • Male Positive (Nonstandard Protocol) 
  • Salmonella  (256166) Completed 
    •  Positive 
  • Sister Chromatid Exchanges  (A74454) Completed 
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
    • Mice

Organ Systems Toxicity

  • 5 CONSECUTIVE DAYS Dominant Lethal (Inhalation)  (T0183A) Completed 
    • Citation: PNL-6545
    • M Mice: Swiss
    • Dose: 200, 1000, 5000 PPM
  • GD 6-15 Conventional Teratology (Inhalation)  (TER85144) Completed 
    • Citation: PNL-6412
    • F Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 40, 200, 1000 PPM
  • GS 6-19 Conventional Teratology (Inhalation)  (TER89041) Completed 
    • Citation: DE88004186/XAB
    • F Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0, 40, 200, 1000 PPM

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Web page last updated on January 22, 2009