Testing Information

Testing Status of Agents at NTP

1,2-Dibromoethane

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http://ntp.niehs.nih.gov/go/TS-10513-F

CASRN: 106-93-4

Formula: C2-H4-BR2

Synonyms/Common Names:

  • EDB
  • ETHYLENE DIBROMIDE

Known Uses:

SCAVENGER FOR LEAD IN GASOLINE; SOIL AND GRAIN FUMIGANT; INTERMEDIATE FOR DYES AND DRUGS

Nomination Background

Short-Term Toxicity

  • 14-Day (Inhalation)  (C00522B) Completed 
    • NTIS No. PB82-181710  (Peer Review 06/27/1980)
      Citation: Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
    • Rats: F344/N; Mice: B6C3F1
  • 13-WEEK (Gavage)  (C00522A) Completed 
    • NTIS No. PB288428  (Peer Review 04/26/1978)
      Citation: Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CAS No. 106-93-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0,40,251 MG/KG/5 PER GROUP
  • 13-Week (Inhalation)  (C00522B) Completed 
    • NTIS No. PB82-181710  (Peer Review 06/27/1980)
      Citation: Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,3,75 PPM/10R - 20M PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C00522A) Report Complete 
    • TR-086 (NTIS No. PB288428)  (Peer Review 04/26/1978)
      Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CAS No. 106-93-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: MR: 0,38,41 (AVG), FR: 0,37,39 (AVG), M: 0,62,107 MG/KG/50 PER GROUP
  • 2-Year (Inhalation)  (C00522B) Report Complete 
    • TR-210 (NTIS No. PB82-181710)  (Peer Review 06/27/1980)
      Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,10,40 PPM/50 PER GROUP

Special Studies

  • Cell Proliferation  (S0762) Completed 
    • Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMICALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
    • M Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (738945) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (665769) Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (782145) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma (NCI)  (G50253) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (G62050) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Micronucleus  (A71010) Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella (NCI)  (N-9282) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (529327) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 
  • Sister Chromatid Exchanges  (738945) Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Biochemical Specific Locus  (BSLM37) Completed 
    • Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
    • M Mice: DBA/2J
    • Mice Male Negative 
  • Dominant Lethal (Male)  (DLM021) Completed 
    • Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
    • M Mice: DBA/2J
    • Mice Male Negative 
  • Total Reproductive Capacity  (TRC98012) Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns ofFemale Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • F Mice
    • Mice Female Negative 

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Web page last updated on January 22, 2009