National Toxicology Program

CASRN: 105-87-3

Formula: C12 H20 O2

Synonyms/Common Names:

• ACETIC ACID GERANIOL ESTER (9CI)

Known Uses:

FRAGRANCE IN COSMETIC CREAMS, LOTIONS, PERFUMES, SOAPS AND DETERGENTS. FLAVOR IN FOODS AND BEVERAGES. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C54728) Completed 
  • NTIS No. PB88-174313  (Peer Review 09/22/1982)
    Citation: Carcinogenesis Studies of Food Grade Geranyl Acetate (71 Geranyl Acetate, 29Citronellyl Acetate) (CAS No. 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54728) Completed 
  • NTIS No. PB88-174313  (Peer Review 09/22/1982)
    Citation: Carcinogenesis Studies of Food Grade Geranyl Acetate (71 Geranyl Acetate, 29Citronellyl Acetate) (CAS No. 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,250,4000, M: 0,125,2000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C54728) Report Complete 
  • TR-252 (NTIS No. PB88-174313)  (Peer Review 09/22/1982)
    Carcinogenesis Studies of Food Grade Geranyl Acetate (71 Geranyl Acetate, 29Citronellyl Acetate) (CAS No. 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (125080) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• Chromosome Aberrations  (A07926) Completed 
  • Mice
  • Chromosome Aberation  Negative (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (076096) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Drosophila  (686825) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (340860) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Micronucleus  (045954) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A07926) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (139724) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Sister Chromatid Exchanges  (125080) Completed 
  • Mice
  • Sister Chromatid  Negative