National Toxicology Program

CASRN: 105-55-5

Formula: C5-H12-N2-S

Synonyms/Common Names:

• 1,3-DIETHYL-2-THIOUREA

Known Uses:

CORROSION INHIBITOR; VULCANIZATION

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03816) Completed 
  • NTIS No. PB288626  (Peer Review 08/31/1978)
    Citation: Bioassay of N,N'-Diethylthiourea for Possible Carcinogenicity (CAS No. 105-55-5)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03816) Completed 
  • NTIS No. PB288626  (Peer Review 08/31/1978)
    Citation: Bioassay of N,N'-Diethylthiourea for Possible Carcinogenicity (CAS No. 105-55-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,147,464, M: 0,680,3150 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03816) Report Complete 
  • TR-149 (NTIS No. PB288626)  (Peer Review 08/31/1978)
    Bioassay of N,N'-Diethylthiourea for Possible Carcinogenicity (CAS No. 105-55-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,125,250, M: 0,250,500 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (481340) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (215943) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (142424) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (013090) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative