National Toxicology Program

CASRN: 103-85-5

Formula: C7-H8-N2-S

Synonyms/Common Names:

• PHENYLTHIOUREA (9CI)

Known Uses:

GENETICS RESEARCH

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02017) Completed 
  • NTIS No. PB287357  (Peer Review 06/25/1978)
    Citation: Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CAS No. 103-85-5)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02017) Completed 
  • NTIS No. PB287357  (Peer Review 06/25/1978)
    Citation: Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CAS No. 103-85-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,45,215, M: 0,25,810 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02017) Report Complete 
  • TR-148 (NTIS No. PB287357)  (Peer Review 06/25/1978)
    Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CAS No. 103-85-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,60,120, M: 0,150,300 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (575473) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (688781) Completed 
  •  Positive 
• Salmonella  (155526) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative