Testing Status of Agents at NTP
Di(2-ethylhexyl)adipate
CASRN: 103-23-1
Formula: C22-H42-O4
Synonyms/Common Names:
- HEXANEDIOIC ACID, BIS(2-ETHYLHEXYL)ESTER (9CI)
Known Uses:
PLASTICIZER ADDED TO POLYVINYL PLASTICS AND VACUUM PUMP FLUID
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C54386) Completed
- NTIS No. PB82-185927
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CAS No. 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB82-185927
(Peer Review 06/27/1980)
- 13-Week (Dosed-Feed)
(C54386) Completed
- NTIS No. PB82-185927
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CAS No. 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,1600,25000 PPM/10 PER GROUP
- NTIS No. PB82-185927
(Peer Review 06/27/1980)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C54386) Report Complete
- TR-212 (NTIS No. PB82-185927)
(Peer Review 06/27/1980)
Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CAS No. 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Positive
- Female Mice Positive
- Dose: 0,12000,25000 PPM/50 PER GROUP
- TR-212 (NTIS No. PB82-185927)
(Peer Review 06/27/1980)
Genetic Toxicology
- Chromosome Aberrations
(959525) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(783757) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Weakly Positive
- Sister Chromatid Exchange Inconclusive
- Drosophila
(126266) Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(190909) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Negative
- Micronucleus
(719908) Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Negative
- Salmonella
(648372) Completed
- Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
- Negative
- Salmonella
(947372) Completed
- Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
- Negative
- Salmonella
(963935) Completed
- Negative
- Sister Chromatid Exchanges
(959525) Completed
- Mice
- Sister Chromatid Negative
Web page last updated on January 22, 2009