National Toxicology Program

CASRN: 102-50-1

Related: P-CRESIDINE (CAS 120-71-8)

Formula: C8 H11 N O

Synonyms/Common Names:

• 4-METHOXY-2-METHYL-BENZENEAMINE (9CI)

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

• 14-Day (Gavage)  (C02993) Completed 
  • NTIS No. PB286188  (Peer Review 03/06/1978)
    Citation: Bioassay of m-Cresidine for Possible Carcinogenicity (CAS No. 102-50-1)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C02993) Completed 
  • NTIS No. PB286188  (Peer Review 03/06/1978)
    Citation: Bioassay of m-Cresidine for Possible Carcinogenicity (CAS No. 102-50-1)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.02,.3, M: 0,.04,.6 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C02993) Report Complete 
  • TR-105 (NTIS No. PB286188)  (Peer Review 03/06/1978)
    Bioassay of m-Cresidine for Possible Carcinogenicity (CAS No. 102-50-1)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Inadequate Study 
  • Female Mice Negative 
  • Dose: R: 0,.08,.16, M: 0,.06,.11 (AVG) G/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (665516) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9390) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (469273) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive