Testing Status of Agents at NTP
Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
Formula: C12-H14-O4
Synonyms/Common Names:
- DGRE
- 2,2'-(1,3-PHENYLENEBIS(OXYMETHYLENE))BISOXIRANE (9CI)
Known Uses:
DILUENT IN PRODUCTION OF EPOXY RESINS; LIQUID SPRAY EPOXY RESIN; CURING AGENT FOR POLYSULFIDE RUBBER
Short-Term Toxicity
- 14-Day (Gavage)
(C54966A) Completed
- NTIS No. PB87-146734
(Peer Review 02/28/1983)
Citation: Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CAS No. 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1; Rats: F344/N
- NTIS No. PB87-146734
(Peer Review 02/28/1983)
- 13-Week (Gavage)
(C54966A) Completed
- NTIS No. PB87-146734
(Peer Review 02/28/1983)
Citation: Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CAS No. 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1; Rats: F344/N
- Dose: R: 0,12.5,200, M: 0,25,400 MG/KG/10 PER GROUP
- NTIS No. PB87-146734
(Peer Review 02/28/1983)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C54966A) Report Complete
- TR-257 (NTIS No. PB87-146734)
(Peer Review 02/28/1983)
Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CAS No. 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Dose: R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP
- TR-257 (NTIS No. PB87-146734)
(Peer Review 02/28/1983)
- 2-Year (Gavage)
(C54966A) Report Complete
- TR-257 (NTIS No. PB87-146734)
(Peer Review 02/28/1983)
Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CAS No. 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R: 0,12,25,50, M: 0,50,100 PPM/50 PER GROUP
- TR-257 (NTIS No. PB87-146734)
(Peer Review 02/28/1983)
Special Studies
- Cell Proliferation
(S0758) Completed
- Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMCALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
- M Rats: F344/N
Genetic Toxicology
- Chromosome Aberrations
(389996) Completed
- Mice
- Chromosome Aberation Positive
- Chromosome Aberrations
(873378) Completed
- Mice
- Chromosome Aberation Positive (Nonstandard Protocol)
- In Vitro Cytogenetics (CA/SCE)
(120506) Completed
- Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(586624) Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
- Mouse Lymphoma
(195111) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Positive
- Micronucleus
(367536) Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A56274) Completed
- Mice: B6C3F1
- Male Positive
- Salmonella
(493700) Completed
- Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
- Positive
- Sister Chromatid Exchanges
(389996) Completed
- Mice
- Sister Chromatid Positive
- Sister Chromatid Exchanges
(873378) Completed
- Mice
- Sister Chromatid Positive
Web page last updated on January 22, 2009