National Toxicology Program

CASRN: 101-05-3

Formula: C9 H5 CL3 N4

Synonyms/Common Names:

• 4,6-DICHLORO-N-(2-CHLOROPHENYL)-1,3,5-TRIAZIN-2-AMINE (9CI)
• 2,4-DICHLORO-6-O-CHLORANILINO-S-TRIAZINE

Known Uses:

AGRICULTURAL FUNGICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C08684) Completed 
  • NTIS No. PB287141  (Peer Review 06/29/1978)
    Citation: Bioassay of Anilazine for Possible Carcinogenicity (CAS No. 101-05-3)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C08684) Completed 
  • NTIS No. PB287141  (Peer Review 06/29/1978)
    Citation: Bioassay of Anilazine for Possible Carcinogenicity (CAS No. 101-05-3)
  • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C08684) Report Complete 
  • TR-104 (NTIS No. PB287141)  (Peer Review 06/29/1978)
    Bioassay of Anilazine for Possible Carcinogenicity (CAS No. 101-05-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,500,1000 PPM

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (443411) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma (NCI)  (G52321) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G87759) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9284) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (915261) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative