National Toxicology Program

CASRN: 99-55-8

Formula: C7 H8 N2 O2

Synonyms/Common Names:

• 2-METHYL-5-NITROBENZENAMINE

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01843) Completed 
  • NTIS No. PB285872  (Peer Review 04/26/1978)
    Citation: Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (CAS No. 99-55-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01843) Completed 
  • NTIS No. PB285872  (Peer Review 04/26/1978)
    Citation: Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (CAS No. 99-55-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.009,0.07 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01843) Report Complete 
  • TR-107 (NTIS No. PB285872)  (Peer Review 04/26/1978)
    Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (CAS No. 99-55-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,.005,.01, M: 0,.12,.23 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (012878) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella (NCI)  (N-9370) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (758929) Completed 
  •  Positive