Testing Information

Testing Status of Agents at NTP

Ethylene thiourea (ETU)

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10466-C

CASRN: 96-45-7

Formula: C3-H6-N2-S

Synonyms/Common Names:

  • 2-IMIDAZOLIDINETHIONE (9CI)

Known Uses:

INTERMEDIATE FOR ANTIOXIDANTS, INSECTICIDES, FUNGICIDES, DYES, PHARMACEUTICALS. ACCELERATOR FOR NEOPRENE, EPICHLOROHYDRIN, AND POLYETHYLENE RUBBERS, DEGRADATION PRODUCT OF CERTAIN FUNGICIDES

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03372) Completed 
    • NTIS No. PB92-191618  (Peer Review 04/25/1990)
      Citation: Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS No. 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03372) Completed 
    • NTIS No. PB92-191618  (Peer Review 04/25/1990)
      Citation: Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS No. 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,60,750, M: 0,125,2000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C03372) Report Complete 
    • TR-388 (NTIS No. PB92-191618)  (Peer Review 04/25/1990)
      Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS No. 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,25,83,250, M: 0,100,333,1000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (007998) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Drosophila  (118681) Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Sex-Linked Recessive Lethal Inconclusive 
    • Reciprocal Translocation Negative 
  • Drosophila  (717564) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (669405) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Positive 
  • Salmonella  (123790) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (431394) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90009) Completed 
    • NTIS No. PB92-140383
      Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Citation: SUMMARY (1-15)
    • F Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 1, 3, 10%
  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0042A) Completed 
    • NTIS No. PB83-213017
      Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • F Mice: Swiss
    • Dose: 600 MG/KG BD WT
  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0042B) Completed 
    • NTIS No. PB84-183540
      Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • F Mice: Swiss
    • Dose: 300 MG/KG BD WT
  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0042C) Completed 
    • NTIS No. PB83-258616
      Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • F Mice: Swiss
    • Dose: 200 MG/KG BD WT
  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0042D) Completed 
    • NTIS No. PB83-257600
      Citation: Screening of Priority Chemicals for Reproductive Hazards
    • F Mice: Swiss
    • Dose: 100 MG/KG BD WT

Back to top

Web page last updated on January 22, 2009